Cardioprotective effect of anti-inflammatory drugs

Cardioprotective effect of anti-inflammatory drugsCardioprotective effect of anti-inflammatory drugs Non-steroidal anti-inflammatory drugs have additional cardioprotective effect in patients already receiving aspirin in small doses. Dr. Marie Hudson and her colleagues from the Health Centre, McGill University (Montreal, Canada) presented these data at the 66th annual meeting of the American College of Rheumatology. "At first, we assumed that non-steroidal anti-inflammatory drugs (NSAIDs) can reduce the effect of aspirin, and that patients taking both aspirin and NSAIDs increases the risk of recurrent myocardial infarction (mi)," said Dr. Hudson. However, this hypothesis was not confirmed. In canadian scientists conducted population-based study included 28881 patients 65 years and older who have had THEM in the period from 1 January 1992 to 31 March 1999, All participants took aspirin in small doses (80-325 mg/day). NSAIDs additionally took 21.7% of patients. The most frequently used drugs were diclofenac (6.98%), naproxen (6.09%) and ibuprofen (1.98%). Repeat THEM (during the year from a prior heart attack) moved approximately 7% of patients. After adjusting for confounding factors was found that among those who use NSAIDs in General, the risk of repeated THEM to 23% less than those receiving only aspirin. Standardized odds ratio for naproxen was 0.84 for diclofenac - 0.75, for acetaminophen v 1.14. Thus, there has been a negative action of the combination of aspirin and other NSAIDs on cardiovascular system. Other side effects (e.g. gastrointestinal complications in this study was not investigated. "We have already started the study with a longer observation period to determine long-term effects of combinations of NSAIDs and aspirin, as well as to clarify the differences between individual NSAIDs. In the near future will be obtained similar data for COX-2 inhibitors," said Dr. Hudson. Source:

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